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KMID : 0616120210520020092
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Korean Journal of Pharmacognosy
2021 Volume.52 No. 2 p.92 ~ p.98
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Biological Activity of Fermented Gryllus bimaculatus extracts
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Park In-Sun
Lim Hyeon-Ji
Jeong Seung-Il
Jung Chan-Hun
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Abstract
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Gryllus bimaculatus extract (GbE) have reported that anti-inflammatory activity by suppression of pro-inflammatory cytokines. However, the effects of fermented Gryllus bimaculatus extract (FGbE) have not yet been investigated. In this study, we evaluated the anti-inflammatory and anti-wrinkle effect of the fermented Gryllus bimaculatus extracts using Bacillus subtilis (JB PMB-18) in RAW264.7 cells. Both GbE and FGbE exerted no cytotoxic effects until 1000 μg/mL concentration. FGbE decreased NO production and decreased iNOS and COX-2 mRNA levels in a concentration-dependent manner. In addition, the protein production of inflammatory cytokines TNF-α, IL-1β and IL-6 was effectively reduced compared to the GbE. Inhibitory activities of elastase and collagenase associated with skin wrinkle improvement were measured to be 45% and 69%, respectively, at a concentration of 500 μg/mL in FGbE. From these results, FGbE can be used as a health functional food and skin functional cosmetic materials for preventing inflammatory diseases because it has excellent anti-inflammatory and anti-wrinkle effects.
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KEYWORD
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Gryllus bimaculatus, Gryllidae, Fermentation, Anti-inflammatory, Anti-wrinkle, Cosmetic materials
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